“Father knows best?”

Have you seen ? “ Father knows best ? ” Ashley

Following fertilization, activation of a complex developmental program requires the differential expression of key genes. In most metazoa, the prevailing view is that early differential gene expression occurs primarily through post-transcriptional regulation of maternally deposited products in the oocyte. Two novel studies published from the Rajewsky laboratory in this issue of The EMBO Journal...

Genome Rearrangements: Mother Knows Best!

In Paramecium, developmentally programmed genome rearrangements can be altered by the presence of homologous sequences within the maternal somatic nucleus. Newly identified RNA-binding proteins appear to mediate the transfer of homologous sequence information from the maternal to the developing somatic nucleus, facilitating epigenetic regulation of this large-scale genome reorganization.

Mother knows best: maternal influence on early embryogenesis.

The most important medical source: Aunt Mabel knows best.

Who Knows Best? Education, Partisanship, and Contested Facts

An alert, informed electorate is considered vital to a robust democracy, and the main path to that electorate includes formal education. The educated citizen is politically attentive, knowledgeable, and participatory, and the uneducated citizen is not. However, this fact conceals a less favorable effect of education. Educated citizens possess the cognitive skills to reject facts inconsistent wi...